Database construction for transcriptional regulation in Streptomyces and Synechocystis and these applications

最近在细菌转录网络分析方面的工作表明，转录调控是灵活的，并且进化迅速。因此，建立多种模式生物转录调控的参考数据库具有重要意义。我人工收集近500篇文献资料，构建链霉菌（Streptomyces）和聚囊藻（Synechocystis）的参考数据库。通过收集到的数据，我进行了比较基因组分析和网络基序分析，并提出了转录网络在物种特异性功能中的特异性，例如链霉菌的抗生素合成和聚胞菌的光合作用。

Recent works in bacterial transcriptional network analysis reveal that transcriptional regulations are flexible and evolve rapidly. It is therefore important to construct reference databases on transcriptional regulation of multiple model organisms. I constructed referenced databases in Streptomyces and Synechocystis with manually collected data from nearly 500 literatures. By using the collected data, I performed comparative genome analysis and network motif analysis and suggested specificity of transcriptional networks in species-specific functions, such as antibiotic synthesis of Streptomyces and photosynthesis of Synechocystis.