Mitochondrial targeting signal is major determinant of mitochondrial localizing mRNA

线粒体功能障碍与阿尔茨海默氏症和其他疾病有关，但用于维持线粒体的细胞机制仅部分了解。 因此，我们研究了蛋白质向线粒体中的转运，并定量显示这些蛋白质的特定区域比其他蛋白质进化得更快（BMCGenomics 2014）。 此外，我们研究了线粒体附近的mRNA分子的定位。 我们通过对几个已发表的数据集进行综合统计分析来做到这一点。 根据我们的分析结果，我们提出了一个新的假设-蛋白质的合成（翻译起始）时间越长，它们就越有可能定位于线粒体的外围。 通过提供对负责线粒体维持的机制的见解，未来我们的结果可能有助于预防或治疗线粒体相关疾病的进展。

Mitochondria dysfunction has been implicated in Alzheimer's and other diseases, but the cellular mechanisms used to maintain mitochondria are only partially understood. Thus we investigated the transport of proteins into the mitochondria and quantitatively showed that a particular region of those proteins evolves faster than other proteins (Fukasawa et al. BMC Genomics 2014). In addition we investigated the localization of mRNA molecules in the vicinity of mitochondria. We did this by integrative statistical analysis of several published datasets. Based on the results of our analysis we propose a novel hypothesis -- that the longer it takes for proteins to be made (translation initiation), the more likely it is that they localize to the periphery of the mitochondria. By providing insights into the mechanisms responsible for maintenance of mitochondrial, in the future our results may contribute to advances in the prevention or treatment of mitochondria related disease.