Elucidation of Interfacial Structure and Functionality of the Biomembrane on the ECM

细胞膜表面通常覆盖着细胞外基质（extracellular matrix， ECM），它控制着细胞膜表面的局部环境，强烈地影响着细胞膜的功能。然而，与ECM的结构和功能关系相关的一些问题仍然不清楚。在本研究中，为了了解ECM的功能，我们在分子水平上用和频产生（SFG）振动谱和原子力显微镜（AFM）表征了一系列可作为ECM的生物相容性材料的界面分子结构，如含环糊精的聚轮烷超分子、聚合物电解质和阳离子表面活性剂分子。所获得的信息有助于通过控制其界面结构来理解ECM的功能。

The surface of cell membrane is typically covered by the extracellular matrix (ECM), which controls the local environment of the cell membrane surface and strongly affects functionality of the cell membrane. However, a number of issues related to the relationship of the structure and functionality of ECM are still unclear. In the present study, to understand the functionality of the ECM, the interfacial molecule structures of a series of biocompatible materials which could be employed as ECM, such as polyrotaxane supramolecules with cyclodextrin hosts, polymer electrolyte and cationic surfactant molecules, have been characterized by the sum frequency generation (SFG) vibrational spectroscopy and atomic force microscope (AFM) at a molecular level. The information obtained is useful to understand the functionality of ECM by controlling their interfacial structures.