Elucidation of pathological role of NGAL as a modulator of kidney function, metabolism and immune system

NGAL KO小鼠腺嘌呤肾病加重。80%的血液NGAL来源于白细胞，而尿液NGAL主要由肾脏合成。在慢性肾脏疾病中，尿NGAL与polyIg受体或a2-巨球蛋白部分结合，并与肾脏病理改变的严重程度相关。在高脂饮食下，NGAL - KO小鼠表现出抗肥胖的能力。血液中NGAL水平低的血液透析患者出现营养不良和严重感染的风险增加。用LPS处理WT小鼠可引起脑炎症，减少运动活动和识别功能障碍，而这些变化在KO小鼠中得到改善。在特发性肺纤维化患者的BAL液和肺活检样本中NGAL表达升高。

NGAL KO mice exhibited worsening of adenine nephropathy. 80% of blood NGAL was derived from leukocytes, while urinary NGAL was mainly synthesized by the kidney. In chronic kidney disease, urinary NGAL was partly bound to polyIg receptor or a2-macroglobulin, and showed correlation with severity of renal pathologic changes. Under high fat diet, NGAL KO mice showed resistance against obesity. Hemodialysis patients having low blood NGAL levels showed increased risk to have malnutrition and to develop severe infection. Treatment of WT mice with LPS induced brain inflammation, reduced motor activity and recognition impairment, and these chnges were ameliorated in KO mice. NGAL expression was increased in BAL fluid and lung biopsy samples from patients with idiopathic pulmonary fibrosis.