Identification of genetic polymorphisms associated with onset of neuropathic pain and therapeutic efficacy

神经性疼痛易感性和治疗责任的巨大个体差异阻碍了神经性疼痛的有效治疗。在本研究中，我们专注于双侧升支矢状劈开截骨术（BSSRO），这是一种常见的正颌外科手术，在某些患者中会导致周围神经障碍，而在其他患者中则不会。我们对360名患者进行了全基因组关联研究，发现位于ARID1B和ZPLD 1基因的遗传多态性与感觉减退之间以及位于胃L4基因的遗传多态性与感觉迟钝之间存在关联。

Huge individual differences in vulnerability to neuropathic pain and in responsibility to its therapy hamper effective therapy for neuropathic pain. In the present study, we focused on bilateral sagittal split ramus osteotomy (BSSRO) which is a common orthognatic surgical procedure and causes peripheral nerve disturbances in some patients and not in the others. We conducted genome wide association study in 360 patients and found associations between genetic polymorphisms located in the ARID1B and ZPLD1 genes and hypoesthesia and between a genetic polymorphism in the METTL4 gene and dysesthesia.