Function and structure of food-derived and endogenous collagen peptide in damaged regions of skin

目前的研究表明，前-Hyp存在于小鼠的炎症和创面愈合区域。已经证实，人摄入胶原肽后，血液中存在前-羟色胺。此外，原代培养的小鼠皮肤成纤维细胞表达间充质干细胞标记物(P75NTR)和多肽转运体，并掺入Pro-Hyp并开始在胶原胶上生长，传代后大量减少。本研究证实了Pro-Hyp在伤口愈合过程中的重要作用，并探讨了通过摄取胶原肽促进伤口愈合的机制。

The present study demonstrates that occurrence of Pro-Hyp in the inflammatory and wound healing regions of mice. Pro-Hyp has been demonstrated to be present human blood after ingestion of collagen peptide. In addition, primary cultured fibroblast from mouse skin expressed mesenchymal stem cell marker (p75NTR) and peptide transporters and incorporated Pro-Hyp and started to grow on collagen gel, which were extensively decreased after passage. The present study demonstrates the significant role of Pro-Hyp in wound healing process and explores mechanism for enhance meant of wound healing by ingestion of collagen peptide.