Regulation of plasmalogen synthesis and establishment of plasmalogen diversity

本研究旨在探讨等离子体合成调控的分子机制。Plasmalogen是甘油磷脂的一个亚型，其中一个长链脂肪醇通过乙烯醚键在sn-1位置连接。过氧化物酶体脂肪酰基辅酶a还原酶1 （Far1）是提供在聚醛原合成中形成醚键所需的脂肪醇所必需的。Plasmalogen的合成是通过调节Far1的稳定性以一种依赖于Plasmalogen的方式来调节的。在这里我发现Far1是一种过氧化物酶体尾部锚定蛋白。Far1，而不是Far2，在细胞水平上被优先降解。Far1跨膜结构域两侧的区域是Far1依赖于质糖原降解所必需的。聚脂原的多样性是通过脂肪酸的重塑形成的，Far1的稳定性依赖于某些类型的聚脂原。

The aim of this study is to investigate molecular mechanism of the regulation of plasmalogen synthesis. Plasmalogen is a subtype of glycerophospholipids, in which a long chain fatty alcohol is linked at sn-1 position through a vinyl ether bond. Peroxisomal fatty acyl-CoA reductase 1 (Far1) is essential for supplying fatty alcohols required for ether bond formation in plasmalogen synthesis. Plasmalogen synthesis is regulated by modulating Far1 stability in a plasmalogen-dependent manner.Here I found that Far1 is a peroxisomal tail-anchored protein. Far1, but not Far2, was preferentially degraded in response to the cellular level of plasmalogens. The region flanking the transmembrane domain of Far1 is required for plasmalogen-dependent degradation of Far1. The diversity of plasmalogens was formed through remodeling of fatty acids and Far1 stability is regulated in a manner dependent on certain type of plasmalogens.