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Clarified the active mechanisms of the multiple functions of mushrooms within the human body after consumption

Clarified the active mechanisms of the multiple functions of mushrooms within the human body after consumption
阐明食用菌多种功能在人体内的激活机制
批准号:
23580234
负责人:
EGUCHI FUMIO
金额:
$3.16万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2013

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中文摘要
翻译
研究表明,香菇热水提取物具有抑制血小板聚集的作用。血小板聚集是由血小板与PAF受体结合引起的。许多蘑菇的抑制血小板聚集作用不仅通过COX代谢促进TXA2,PLA2和1-烷基磷脂酰胆碱(一种细胞膜磷脂)再生区域的活性也被证实。此外,ADP的产生受到抑制,这源于从血管内皮细胞破裂到致密颗粒血小板产生的过程。由于蘑菇是一种广泛的抑制血小板聚集功能的活性物质,现在已知经常食用蘑菇可以通过刺激血管、中性粒细胞激活和平滑肌收缩、改善肾性高血压和其他与血小板聚集有关的功能来改善血管内皮疾病的症状。
英文摘要
It has been shown that mushroom basidiocarp hot water extract suppresses platelet aggregation. Platelet aggrgation is caused by platelets binding to PAF receptors. The platelet aggregation suppression effect of many mushrooms not only promotes TXA2 through COX metabolism, both PLA2 and activity in the domain of regeneration of 1-alkyl phosphatidycholine, a cell membrane phospholipid, have also been confirmed. Also, suppression of ADP's production, which stems from the process passing from breakdown of vascular endothelials to dense granule platelet production, has been shown. Because mushroom are an active material in a wide range of platelet aggregation suppressive functions, regularly eating mushrooms is now known to contribute to improving the symptoms of vascular endothelial diseases by stimulating the blood vessels, neutrophil activation, and smooth muscle contraction, improving renal hypertension, and aiding other functions related to platelet aggregation.
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发表时间: 2011
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发表时间: 2012
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影响因子: --
作者: [木田マリ, 宮澤紀子, 吉本博明, 江口文陽]
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DOI: --
发表时间: 2011
期刊: Mushroom Science and Biotechnology 19(1)
影响因子: --
作者: [Fumio EGUCHI, Noriko MIYAZAWA, Takahide MATSUDA]
通讯作者: Takahide MATSUDA
共 20 条
    Elucidation of the multifunctional expression of mushrooms based on inflammatory regenerative medicine and neuroscience
    • 批准号:
      20H03050
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.23万
    • 财政年份:
      2020
    • 负责人:
      EGUCHI FUMIO
    • 依托单位:
    The development of cultivation technology of highly advanced functional mushroom for age-related diseases and the evaluation of its efficacy
    • 批准号:
      26450235
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.24万
    • 财政年份:
      2014
    • 负责人:
      EGUCHI FUMIO
    • 依托单位:
    海外基金