Studies on molecluar mechanism of lipid droplet formation in telesot oocytes

硬骨鱼的卵母细胞在其生长阶段积累了大量的脂质和蛋白质；它们后来通过发育胚胎和幼虫被用作能量和营养资源。然而，人们对这些脂质的起源和它们在卵母细胞中积累的机制知之甚少。在本研究中，我们旨在从分子水平上阐明其机制。结果首次证实血浆极低密度脂蛋白是中性脂质向卵母细胞脂滴的主要载体，并更新了卵母细胞脂化模型。

In teleost fishes, high amount of lipids and proteins are accumulated in oocytes during their growth phase; they are later utilized as energy and nutrient resources by developing embryos and larvae. However, little is known about the origin of such lipids and the mechanisms underlying their accumulation into oocytes. In the present study, we aimed to clarify the mechanisms at the molecular levels. As the results, we confirmed that, for the first time, plasma very low density lipoprotein is the major carrier of neutral lipid to oocyte lipid droplets, and updated the model for the oocyte lipidation.