Cooperative and antagonistic interaction between progesterone and eicosanoid in the ovary

我们的研究结果如下。1)排卵前成熟卵泡对COX-2的诱导可能与P4等甾体代谢的串扰以及GIVA PLA2代谢物的前馈/反馈机制有关。2)颗粒层的PGE合成酶尚不明确。3)在循环大鼠自然回归CL中，自体毒素是通过GIVA PLA2下游功能诱导并参与组织重塑的新因子。4)该蛋白在妊娠CL中也有诱导作用，可能在CL调控中有明显作用。基于这一事实和Fas表达的本质，妊娠CL、假性妊娠CL和循环CL之间存在着根本的区别。

Our findings are as follows. 1) COX-2 induction by the preovulatory mature follicles could be regulated by a crosstalk with the metabolism of steroid including P4 and by a feedforward/feedback mechanism involving GIVA PLA2 metabolites. 2) PGE synthase in the granulosa layers remains undefined. 3) In naturally regressing CL of cycling rats, autotoxin was identified to be a novel factor that was induced and contributed to tissue remodeling via function downstream of GIVA PLA2. 4) This protein was also induced in CL of pregnancy and supposed to have distinct roles in CL regulation. With this fact and the nature of Fas expression, there is a fundamental difference among CL of pregnancy, pseudopegnancy, and the cycling.