Reproductive roles of the adipsin/ASP pathway mediated by immunological and lipid methabolic effects

脂酶/天冬氨酸系统在补体激活和细胞脂质摄取过程中具有串扰效应。探讨脂肪酶/天冬氨酸系统在生殖生理和流产发生中的作用。流产胎盘中甘油三酯及相关因子升高，血管壁脂滴增多。给妊娠小鼠注射重组脂肪酶可降低流产率，促进胎盘组织学退变。脂肪酶治疗后脂代谢因子和妊娠相关细胞因子发生变化。Adipsin主要在妊娠期的乳房腺中产生。提示妊娠期脂蛋白/天冬氨酸系统基本调节脂代谢，异常激活可通过代谢因子和细胞因子的全身性变化以及对胎盘形成的局部毒性作用而干扰正常妊娠。

The adipsin/ASP system has a crosstalk effect in the processes of complement activation and cellular lipid uptaken. Involvement of adipsin/ASP system was examined in the reproductive physiology and abortion onset. In the abortion placenta, triglyceride and the related factors were elevated, and lipid droplets were increased in the vascular wall. Administration of recombinant adipsin to pregnant mice elavated abortion rate and promoted histological degeneration of the placenta. Lipid metabolic factors and pregnancy-associated cytokines were changed follwoing the adipsin treatment. Adipsin was produced mainly in the mammaly gland during pregnancy periods. It was suggested that adipsin/ASP system basically regulate lipid metabolism during pregnancy and abnormal activation could disturb normal pregnancy by systemic variation of mataboloc factors and cytokines, and by local toxic effects on the placental formation.