Analysis of neuroprotective effect of pigment epithelium derived factor

色素上皮衍生因子(PEDF)是一种50 kDa的分泌型糖蛋白，是丝氨酸蛋白酶抑制因子(SERPIN)基因家族中的非抑制性成员。PEDF广泛存在于人类组织中，包括几乎所有的脑区，并被证明对小脑颗粒神经元、海马神经元、纹状体神经元、视网膜神经元和脊髓运动神经元等多种类型的神经元具有很强的神经保护作用。这些观察结果表明，PEDF的应用可能有助于设计神经退行性疾病的新治疗策略。在这项研究中。我们检测了PEDF在体内和体外的神经保护作用。

Pigment epithelium-derived factor (PEDF) is a 50-kDa secreted glycoprotein and a non-inhibitory member of the serine protease inhibitor (SERPIN) gene family. PEDF is detected in a broad range of human tissues, including almost all brain areas, and has been shown to have strong neuroprotective properties for various types of neurons including cerebellar granule neurons, hippocampal neurons, striatal neurons, retinal neurons and spinal cord motor neurons.These observations raise thepossibility that application of PEDF may be helpful in designing new therapeutic strategies forneurodegenerative diseases. In this study. we tested neuroprptective effect of PEDF in vivo and in vitro.