Control of multiwall carbon nanotube-induced inflammatory responses by cellular cholesterol

由于碳纳米管具有类似石棉的形状和尺寸，人们对它们对环境和健康的不利影响感到担忧。 研究表明，它们与炎症、间皮瘤和小鼠动脉粥样硬化进展有关。在这项研究中，我们研究了多壁碳纳米管（MWCNT）诱导的炎症细胞因子IL-1 β的产生受胆固醇调节的机制。 我们发现，多壁碳纳米管被纳入THP-1巨噬细胞和诱导IL-1 β成熟通过NLRP 3炎性小体激活。 这种效果是增强了多壁碳纳米管与肺表面活性剂样磷脂分散。 各种他汀类药物通过减少细胞对多壁碳纳米管的摄取来抑制多壁碳纳米管诱导的IL-1 β释放。

Because cnanotubes have asbestos-like shape and size, concerns about their adverse effect on environment and health have been raised. Studies have shown their association with inflammation, mesothelioma, and atherosclerosis progression in mice. In this study, we investigated the mechanism by which multiwall carbon nanotubes (MWCNT)-induced production of an inflammatory cytokine IL-1beta is regulated by cholesterol. We found that MWCNTs were incorporated into THP-1 macrophages and induced IL-1beta maturation via NLRP3 inflammasome activation. This effect is enhanced by dispersion of MWCNTs with lung-surfactant-like phospholipids. Various statins repressed MWCNT-induced IL-1beta release by reducing cellular uptake of MWCNTs.