Identification and therapeutic application of metastasis-related biomarkars in soft tissue sarcomas.

1)我们发现谷胱甘肽过氧化物酶1（GPX-1）可能作为骨巨细胞瘤（GCTB）早期复发和转移的生物标志物。此外，p53突变诱导的GPX-1过表达可能在gctb的恶性转化中发挥重要作用。2)我们发现成纤维细胞生长因子受体（FGFR4）是促结丝增生小圆细胞瘤中EWS-WT1的转录靶点，FGFR4可能是该肿瘤的治疗靶点。3)我们发现DDX39和KCTD10可作为胃肠道间质瘤预后的生物标志物。

1) We showed a possible role of glutathione peroxidase1(GPX-1) as a biomakar for early recurrence and metastasis in giant cell tumor of bone (GCTB). Inaddition, overexpression of GPX-1 induced by p53 mutation would have an important role in the malignant transformation of GCTB.2) We showed that fibroblast growth factor receptor(FGFR4) is a trnascriptional target of EWS-WT1 in desmoplastic small round cell tumor, and FGFR4 and as a possible terapeutic target in this tumor.3) We showed DDX39 and KCTD10 as biomakars for prognosis in gastrointestinal stromal tumor.