Behavioral study on analgesic effect of ATP sensitive potassium channel openers

采用大鼠神经性疼痛模型研究ATP敏感钾通道开放剂的镇痛作用。雄性Sprague-Dawley大鼠坐骨神经慢性收缩损伤。结构不同的药物，二氮氧化合物、品酸酯和尼可地尔被施用于鞘内或脑室内，以检查对机械、热和冷痛觉过敏的中枢作用。这些药物以剂量依赖的方式应用于脊柱和椎管上，减轻机械性和冷性痛觉过敏，但它们对热性痛觉过敏没有影响。ATP敏感的钾通道打开剂可能在脊髓和脑中发挥抗痛觉作用。

The analgesic effects of ATP sensitive potassium channel openers were examined using a rat neuropathic pain model. Chronic constriction injury to the sciatic nerve was induced in male Sprague–Dawley rats. Structurally distinct drugs, diazoxide, pinacidil, and nicorandil were administered intrathecally or intracerebroventricularly to examine the central effects on mechanical, thermal, and cold hyperalgesia. These drugs applied spinally and supraspinally attenuated mechanical and cold hyperalgesia in a dose-dependent manner, but they had no effect on thermal hyperalgesia. The ATP sensitive potassium channel openers may exert antihyperalgesic effects both in the spinal cord and brain.