The association of thigh muscle area and CT attenuation measured by CT with metabolic diseases

我们研究了计算机断层扫描（CT）测量的单层大腿肌肉面积是否可以替代连续磁共振成像扫描测量的大腿肌肉体积。本验证研究包括57名受试者。在我们的队列研究中，我们分析了1366名男性和女性的大腿肌肉面积和CT测量的CT衰减与代谢性疾病的相关性。在多变量分析中，每公斤体重面积（面积/体重）升高与空腹血糖受损（IFG）或2型糖尿病、正常高血压（BP）或高血压和高血糖症的低患病率相关。CT衰减升高与IFG或2型糖尿病、正常高血压或高血压、高甘油三酯血症和低-高密度脂蛋白血症的低患病率相关。男性或女性的低胰岛素抵抗与面积/体重或CT衰减的增加有关。

We examined whether a single-slice thigh muscle area measured by computed tomography (CT) can be substituted for thigh muscle volume measured with contiguous magnetic resonance imaging scans. This validation study consisted of 57 subjects. Correlation between volume and area was strong (0.864, p<0.001).In our cohort study, we analyzed the association of thigh muscle area and CT attenuation measured by CT with metabolic diseases in 1366 men and women. In multivariate analyses, the elevated area per kg of body weight (area/weight) was associated with the low prevalence of impaired fasting glucose (IFG) or type 2 diabetes, high normal blood pressure (BP) or hypertension, and hypertriglyceridemia. The elevated CT attenuation was associated with the low prevalence of IFG or type 2 diabetes, high normal BP or hypertension, hypertriglyceridemia, and hypo-high-density lipoproteinemia. The elevated area/weight or CT attenuation was related with the low insulin resistance among men or women.