Examination of relationships between serum levels of LDL cholesterol and bone metabolism-related indices as well as bone fracture

临床研究表明，动脉粥样硬化和骨质疏松症通常同时存在于一个患者身上。血脂异常是动脉粥样硬化的既定危险因素，它可能是将这两种疾病联系在一起的候选因素。为了阐明这些问题，这项研究调查了绝经后妇女血清低密度脂蛋白-C与骨密度(BMD)和骨折的关系。Logistic回归分析显示，血清低密度脂蛋白胆固醇水平升高被选为影响普遍存在的非椎体骨折的一个指标。在调整了骨标记物、骨密度和各种指标后，这一结果仍然显著[优势比1.76(1.13-2.73)，p=0.012]。综上所述，高血清低密度脂蛋白水平可能是非VFS的危险因素，与绝经后妇女的骨转换、骨密度、维生素D、虚弱状态或治疗血脂异常药物的使用无关，它可能通过参与骨脆性和动脉粥样硬化而对骨和血管有害。

Clinical studies have shown that both atherosclerosis and osteoporosis are frequently present in one patient. Dyslipidemia is an established risk factor for atherosclerosis, and it may be a candidate that links both disorders. To clarify these issues, this study examined the relationships between serum LDL-C and bone mineral density (BMD) and fractures in postmenopausal women. Logistic regression analyses showed that the increased serum LDL-C level was selected as an index affecting the presence of prevalent non-vertebral fractures. This result was still significant after adjustments for bone markers, BMD and various indices [odds ratio 1.76 (1.13-2.73), p=0.012]. In conclusion, a high serum LDL-C level may be a risk factor for non-VFs independent of bone turnover, BMD, vitamin D, frail status, or use of drugs for dyslipidemia in postmenopausal women, and it may be detrimental to bone, as well as blood vessels, by being involved in both bone fragility and atherosclerosis.