Role of RAS in bone remodeling and protective effect of ARB on bone density

目前的研究表明，血管紧张素II促进软骨细胞的肥大分化独立于高血压，导致骨折愈合延迟。这些数据将提供一个新的治疗策略，侧重于RAS的软骨退行性疾病。此外，我们的临床研究表明，ARB对骨吸收加速的高血压患者，如高年龄卧床不起的废用综合征的妇女的骨吸收的抑制作用。在老年高血压患者中，ARB可能具有额外的有益潜力，以维持卧床患者的骨健康，除了其降压作用。

The present study demonstrated that Ang II promoted hypertrophic differentiation of chondrocytes independently of high blood pressure, resulting in the delay of fracture healing. These data would provide a new therapeutic strategy focusing on RAS for cartilage degenerative disease.Also, our clinical study demonstrated the inhibitory effects of ARB on bone resorption in the hypertensive patients with accelerated bone resorption such as high-aged bed-ridden women with disuse syndrome. In the elderly hypertensive patients, ARB might be expected to have additional beneficial potential to maintain the bone health in bed-ridden patients, beyond its blood pressure-lowering effect.