Establishment of new strategy for preventing the prothrombotic tendency of metabolic syndrome

蛋白S(PS)是一种在蛋白C(PC)抗凝途径中起重要作用的抗凝因子，其功能障碍是日本人的主要血栓形成。对肥胖女性和青壮年女性的临床研究发现，血浆总PS质量浓度与PC和ApoCII的含量呈正相关。加入葡萄酒中的多酚白藜芦醇和降低培养液中的葡萄糖浓度，可降低人肝癌细胞系HepG2细胞PS mRNA的表达。这些结果提示，血浆PS可能与VLDL、IDL等脂蛋白结合，保护代谢综合征血栓前状态。

Protein S (PS) is an anticoagulant factor that plays an important role in the protein C (PC) anticoagulant pathway, and its dysfunction is a main thrombophilia among Japanese. The clinical studies on obese women and young adult women uncovered that total PS mass concentration in plasma is positively correlated with the amounts of PC and ApoCII. The PS mRNA expression in HepG2 cells, a human hepatoma cell line, is decreased by adding resveratrol, a polyphenol present in wine, and by lowering the glucose concentration in culture medium. These results suggest that PS in plasma may bind with lipoproteins, such as VLDL and IDL, and protect the prothrombotic tendency of metabolic syndrome.