The microbiota in inflammatory bowel disease with resistance to anti-TNF therapy.

在这项研究中，我们分析了炎症性肠病（IBD）粪便样本的细菌组成。我们发现其中一种梭状芽孢杆菌在活动性溃疡性结肠炎（UC）中的患病率低于静止性UC。我们用热杀死的这种梭菌刺激UC患者和IBD模型小鼠的结肠炎固有层单核细胞（LPMC）。与对照相比，与梭菌孵育的LPMC产生更高的IL-10量。结果提示梭状芽孢杆菌可能通过诱导IL-10抑制肠道炎症。因此，FS可作为IBD治疗的新策略。

In this study, we analyzed the bacterial composition of fecal samples from inflammatory bowel disease (IBD). We found that the prevalence of one of Clostridia was lower in active ulcerative colitis (UC) than quiescent UC. We stimulated colitic lamina propria mononuclear cells (LPMC) from UC patients and IBD model mice with heat-killed this Clostridia. LPMC incubated with Clostridia produced higher amounts of IL-10 compared to controls. The results suggest Clostridia can suppress intestinal inflammation, probably through IL-10 induction. Therefore FS can be a new strategy of IBD therapy.