AMPD1 plays a role in the regulation of insulin sensitivity.

胰岛素抵抗是糖尿病发病机制中的关键因素。我们通过分析AMPD1缺陷小鼠，研究了AMPD1在葡萄糖和脂质代谢中的功能。AMPD1是AMP催化酶AMP脱氨酶的一种异构体，在骨骼肌中优先表达，并可能改变胰岛素信号通路。我们证明AMPD1缺乏可改善高脂肪饮食挑战引起的糖耐量受损和胰岛素抵抗。在高脂肪饮食挑战中，骨骼肌基因表达谱因AMPD1缺乏而改变。虽然需要进一步的研究来阐明AMPD1在胰岛素信号通路中的靶点，但这些数据表明，抑制AMPD1可能是一种治疗糖尿病的策略。

Insulin resistance is a key factor in the pathogenic mechanisms of diabetes. We have studied the function of AMPD1, an isoform of AMP catalyzing enzyme AMP deaminase, which is preferentially expressed in skeletal muscles and potentially modifies insulin signaling pathway, in the glucose and lipid metabolism by analyzing AMPD1-deficient mice. We demonstrate that AMPD1 deficiency improves impaired glucose tolerance and insulin resistance induced by high fat diet challenge. Gene expression profiles in skeletal muscles were modified by AMPD1 deficiency during high fat diet challenge. Although further studies are necessary to elucidate the targets of AMPD1 in insulin signaling pathway, these data suggest that AMPD1 inhibition could be a therapeutic strategy against diabetes.