Antimicrobial chemotherapy for biofilm-related infection caused by multidrug-resistant pathogen

众所周知，细菌附着在植入物上形成生物膜，例如骨科领域的人工关节或心血管外科的人工瓣膜。在这种情况下，因为抗菌剂难以到达生物膜中的细菌，所以感染性疾病是难治的。在这项研究中，发现克拉霉素的大环内酯类药物去除了约50%的由金黄色葡萄球菌形成的生物膜。因此，建立了耐甲氧西林金黄色葡萄球菌（MRSA）在种植体上形成生物膜污染模型，成为医院感染的难题。金黄色葡萄球菌菌株在72小时后通过克拉霉素和达托霉素的组合处理灭菌。

It is known that bacteria which attached to the implants such as the artificial joints of the orthopedics field or the prosthetic valves of the cardiovascular surgery form biofilms. In this case, because an antibacterial agent is hard to arrive at the bacteria in the biofilms, an infectious disease is intractable. In this study, it was found that the clarithromycin of macrolide removed around 50% of biofilms formed by Staphylococcus aureus. Therefore the biofilm formed contamination model on the implant by MRSA which became the problem for nosocomial infection was made.It was confirmed that biofilm formed S. aureus strains were sterilized 72 hours later by combination of clarithromycin and daptomycin treatment.