An exploration for the reason about accumulation of Vitronectin in the mouse model of Tauopathy

在PS19 tau小鼠海马区穿孔通路中发现了玻璃体连接蛋白（Vn）的积累。PS19小鼠的海马被认为是过度磷酸化tau积累的主要病理区域。有趣的是，在PS19小鼠中，Vn越少，海马萎缩越严重。PS19小鼠与Vn缺失小鼠的杂交证实了海马萎缩的增强。这些发现提示Vn可能对PS19小鼠的神经元丢失具有保护作用。

The accumulation of vitronectin(Vn) in the perforant pathway of hippocampal area was found in PS19 tau mice. The hippocampus of PS19 mice has been known as the primary region of pathology with hyperphosphorylated tau accumulation. Interestingly, less Vn showed more hippocampal atrophy in the PS19 mice. Crossbreeding of the PS19 mice with Vn null mice confirmed the enhanced hippocampal atrophy. These findings suggest that Vn may have a protective function against the neuronal loss in PS19 mice.