Development of molecular Imaging for a new amyloidosis (AD,FAP)

[11C]合成并评价PIB临床使用的质量控制。应用该系统，放射化学产率可达62.7%，放射化学纯度可达95%以上。另一方面，新合成了EMSB（1-（2-甲氧基-乙氧基）-2,5-二（苯基苯乙烯基）苯），得到了（1-（125I-乙氧基）-2,5-二（苯基苯乙烯基）苯）[125I]- eisb。放射化学产率为80 ~ 90%，放射化学纯度为98.4%。我们给老年痴呆模型小鼠注射[125I]-EISB，分析[125I]-EISB在淀粉样蛋白组织中的生物分布（%剂量/g）。动物实验表明，[125I]-EISB的生物分布（%剂量/g）与我们所做的荧光剂MSB和PIB的吸收相似。[125I]-EISB是一种很有前途的检测淀粉样蛋白的新型放射性化合物，使其有可能应用于临床。

[11C]PIB was synthesized and evaluated Quality control for Clinical use. By applying purification system,Radiochemical yield was 62.7% and radiochemical purity was 95% and more. On the other hand, EMSB (1-(2-mestyl-ethoxy)-2,5bis (phenylstyryl)benzene) is newly synthesized and (1-(125I-ethoxy)-2,5-bis (phenylstyryl) benzene) [125I]-EISB was obtained. The radiochemical yield and the radiochemical purity were 80-90% and 98.4% respectively. We injected [125I]-EISB to Alzheimer model mouse and analyzed its bio-distribution (%dose/g) of [125I]-EISB in the amyloid tissues. In the animal experiments showed that the bio-distribution (%dose/g) of [125I]-EISB gave a similar to the uptake as well as fluorescent agents MSB and PIB which have done in our institute. [125I]-EISB was a promising new radio-compound for the detection of the amyloid protein and make it possible to apply it to clinical use.