Assessment of functional and anatomical imaging assessed by PET and cardiac MRI in diabetic cardiomyopathy

为评估糖尿病性心肌病（DMCM）是否与心肌血流量或血流储备有关，5例低LVEF<45% （DMCM）患者和12例LVEF正常的DM对照（DMc）患者行N-13氨PET和心脏MRI（CMR）检查。PET测定应激、静息心肌血流量（sMBF, rMBF）和心肌血流储备（MFR）， CMR测定ESV和EF。两组临床血常规数据差异无统计学意义，但HbA1c （DMCM<DMc）差异有统计学意义。两组间sMBF、rMBF、MFR差异无统计学意义。MFR与LVEF无相关性，但与年龄呈负相关。总之，MBF或MFR不太可能是DMCM发病的一个因素。

To assess whether diabetic cardiomyopathy (DMCM) is related to myocardial blood flow or flow reserve, 5 patients with low LVEF<45% (DMCM) and 12 patients with DM control (DMc) with normal LVEF underwent N-13 ammonia PET and cardiac MRI(CMR). Stress, rest myocardial blood flow (sMBF, rMBF) and myocardial flow reserve (MFR) by PET and EDV, ESV and EF by CMR were evaluated. There was no significant difference in routine clinical blood data, but significant difference in HbA1c (DMCM<DMc). There was no significant difference in sMBF, rMBF and MFR between the 2 groups. MFR was not correlated with LVEF, but showed negative correlation with age among the all patients. In conclusion, MBF or MFR is not likely to be a factor of pathogenesis for DMCM.