Establishment and validation of corrected SUVmax correlated with prognosis following stereotactic body radiotherapy for non-small cell lung cancer

SUVmax是FDG-PET积累的一个指标，有望成为多种癌症的预后因素。但它是一个相对指标，受肿瘤大小、呼吸运动、肿瘤背景、仪器等因素的影响。我们做了一个运动幻体的实验，尝试用肿瘤大小和呼吸运动来修正SUVmax。其次，对非小细胞癌患者立体定向放疗的治疗结果数据，探讨校正后的SUVmax的可用性。结果表明，实际SUVmax和校正SUVmax与局部控制和无病控制具有良好的相关性。然而，修正后的SUVmax并没有显示出与这些结果有更大的相关性。

SUVmax is an index of accumulation in FDG-PET, and is expected to be a prognostic factor of various cancer. However, it is a relative index and is affected by tumor size, respiratory movement, tumor background, instrument and so on. We made an experiment using moving phantom and tried to correct SUVmax modified with tumor size and respiratory movement. Next, availability of the corrected SUVmax was investigated on the treatment results data of stereotactic body radiotherapy for patients with non-small cell cancer.As results, actual SUVmax and corrected SUVmax were correlated well with local control and disease-free control. However, corrected SUVmax was not shown to be more correlated with those outcomes.