Development of new biodegradable hybrid artificial vascular graft with nanotechnology

我们开发了一种新的聚合物用于可生物降解的血管移植物。我们利用纳米技术对聚合物表面进行处理，成功地改变了聚合物的细胞粘附性。聚合物由聚乳酸和聚己内酯的多嵌段共聚物制成。我们制作了一种新的膜，将其水解到表面，发现膜表面多孔，便于细胞进入，从而促进了膜的生物吸收。然后，我们利用电子主轴技术从聚合物中开发了一种新的纳米纤维片。薄片与薄膜对比，张力强，组织亲和性高。目前，我们正在用一种新的聚合物开发一种人工血管移植物。

We developed a new polymer for a biodegradable vascular graft. We have treated its surface of polymer with nanotechnology and succeeded in changing the cell adhesion of the polymer. Polymer is made from a multi-block copolymer of poly-lactic acid and poly-caprolactone. We create a new film, which was hydrolyzed to the surface, it was found that the surface of films is porous and cell entry is facilitated, as a result, bio-absorption of the film is promoted. Then we developed a new sheet with nanofibers from the polymer using an electronic spindle technology. The sheet was compared with the film, the tension is strong and tissue high affinity was revealed. Currently, we have developing an artificial vascular graft with a new polymer.