Experimental examination of the pulmonary emphysema treatment with fetal lung tissues transplantation - a pig emphysema model -

我们已经证明，胚胎肺组织植入正常成年大鼠肺或博来霉素诱导的纤维化肺存活、分化和生长。本研究探讨胎儿肺组织移植到成人肺实质治疗肺气肿的可能性。并执行了一些相关子项目。假腺期移植猪胎儿肺组织在免疫抑制作用下在naïve猪受体肺中存活。猪肺气肿模型的制作还需要进一步的检查。在子项目中，胚胎小鼠肺碎片在苍白小鼠的肺气肿肺中存活并分化。在大鼠移植模型中，受体给予糖皮质激素可促进植入胎儿肺组织的发育和生长。这些影响的增加取决于糖皮质激素给药的持续时间。

We have shown that fetal lung tissues implanted into normal adult rat lungs or bleomycine induced fibrotic lungs survive, differentiate and grown. In this study, the possibility of the pulmonary emphysema treatment with fetal lung tissue transplantation into adult lung parenchyma was examined. And some associated subprojects were performed. Implanted pig fetal lung tissues of the pseudoglandular stage survived in recipient lungs of naïve pig under immunosuppression. Further examination is necessary for the making of the pulmonary emphysema model in the pig. In subprojects, fetal mouse lung fragments survived and differentiated in the emphysematous lung of pallid mice. And in rat transplantation model, administration of glucocorticoid to recipient facilitated the development and growth of implanted fetal lung tissues. These effects was increased depend on the duration of glucocorticoid administration.