Development of diagnostic imaging for detection of epileptogenic foci

难治性癫痫的致痫灶检测是制定手术治疗方案的重要依据。低侵入和准确的诊断成像方法的发展是值得期待的。基于先前在少数患者中进行的一项初步研究，我们建议在I-123 iomazenil脑SPECT中基于mri的部分体积效应校正（PVC）提高皮质癫痫灶的可探测性。在本研究中，基于mri的PVC在I-123 iomazenil脑SPECT中提高皮质癫痫灶检测的有效性是通过对相对较大样本量的调查来建立的。此外，我们还建立了实验环境，以开发用于脑血管疾病或癫痫小动物模型的PET和/或MRI成像方法。我们制作慢性脑灌注不足模型大鼠，利用这些成像方式评估其脑血流量、脑氧代谢和脑炎症。

Detection of epileptogenic foci in intractable epilepsy is most important for planning of operative therapy. Development of low-invasive and accurate method for diagnostic imaging is expected. We suggested, based on a previous pilot study conducted in a small number of patients, that MRI-based partial volume effect correction (PVC) in I-123 iomazenil brain SPECT improves the detectability of cortical epileptogenic foci. In the present study, the effectiveness of MRI-based PVC in I-123 iomazenil brain SPECT in improving the detection of cortical epileptogenic foci was established by the investigation conducted on a relatively large sample size. In addition, we established experimental environment to develop PET and/or MRI imaging methods for small animal models of cerebrovascular disease or epilepsy. We made chronic cerebral hypoperfusion model rats, and evaluated their cerebral blood flow, cerebral oxygen metabolism, and brain inflammation by using these imaging modalities.