Development of an animal model in which neurogenic intermittent claudication is reproduced

神经源性间歇性跛行是腰椎管狭窄症的特征性症状。在本研究中，再现了与间歇性跛行相对应的异常神经元活动，以了解其病理生理学。在腰椎管狭窄症动物模型上，压迫马尾神经可使感觉活动异常增加，低氧条件下这种反应进一步增强，高氧条件下这种反应减弱。反应的程度与背根神经节的氧供应有关。提示慢性压迫引起的感觉神经敏感和氧供动力学改变是神经源性间歇性跛行的主要因素。

Neurogenic intermittent claudication is a characteristic symptom of lumbar spinal canal stenosis. In the present study, abnormal neuronal activities corresponding to intermittent claudication was reproduced to understand the pathophysiology. Using animal model of lumbar canal stenosis, abnormal sensory activities was increased by compression of cauda equina.This reaction was further increased by hypoxic condition, and decreased by hyper-oxygenic condition. The degree of reaction was related to oxygen supply to dorsal root ganglia. These results indicated that sensory nerve sensitization by chronic compression and dynamics of oxygen supply are major factors of neurogenic intermittent claudication.