Osteoconductive effect of spatial design and thermal oxidation on Pure Ti and Ti-15Zr-4Ta-4Nb alloy

钛及其合金表面形成的磷灰石在骨缺损植入时具有诱导骨传导的效果。其中一种方法是“葡萄技术”，通过这种技术，钛及其合金被开槽并进行热处理。本研究的目的是研究该技术在骨缺损植入植骨时的骨传导效果。利用该技术制备的Ti-15Zr-4Nb-4Ta合金，观察成骨细胞在合金表面的生长形态、增殖能力和分化活性。结果表明，采用GRAPE技术加工Ti-15Zr-4Nb-4Ta合金，可促进成骨细胞的生长和分化，达到良好的骨固定效果。

Apatite formation on the surface of titanium and its alloys is effective for inducing osteoconductivity when implanted in bony defects . One of these approaches is "GRAPE Technology," by which titanium and its alloys is grooved and thermally treated. The aim of this study was to investigate the osteoconductive effects of this technology when implanted using bone grafting in bony defects. Using Ti-15Zr-4Nb-4Ta alloy processed by this technique, we assessed the growth morphology, proliferative capacity, and differentiation activity of osteoblasts on the alloy. It was suggested that Ti-15Zr-4Nb-4Ta alloy processed employing GRAPE Technology, might enhance the growth rate and differentiation of osteoblasts to achieve favorable bone fixation .