Postoperative impairment of cognitive function in rats: A possible role of preoperative restraint stress induced microglial activation

本研究旨在观察术前2小时束缚应激对成年和老年大鼠手术后小胶质细胞活化、海马区IL-1β表达及空间工作记忆的影响。6-8月龄成年大鼠在手术前接受2小时的束缚应激，术后空间工作记忆受到影响。在18-20个月龄的大鼠中，手术本身导致了术后空间工作记忆的损害。然而，在接受手术前2小时束缚应激的老年大鼠，即使在术后14天，这种损害仍在继续。这些与小胶质细胞激活和海马神经元上IL-1β表达增加有关。

This study was conducted to evaluate the effect of preoperative 2 hrs restraint stress on microglial activation, an expression of interleukin-1beta in hippocampus and spatial working memory after surgery in adult and aged rats. Spatial working memory was affected after surgery in a 6-8 months adult rat undergoing preoperative 2 hrs restraint stress. In a 18-20 months aged rat, surgery itself induced postoperative impairment of spatial working memory. However, the impairment continued even on the 14 postoperative days in an aged rat undergoing preoperative 2 hrs restraint stress. Those were associated with microglial activation and an increased expression of interleukin-1beta on neuron in hippocampus.