The effect of exercise training on ischemia-reperfusion injury of the steatoliver

脂肪变性肝脏在肝脏手术和肝移植过程中易受缺血再灌注(I/R)损伤。建议进行运动训练，以预防肥胖相关的疾病。然而，运动训练是否能减轻脂肪变性肝脏的I/R损伤尚不清楚。在麻醉和肝脏隔离灌流条件下，采用高血压性的大冢长伊万斯德岛肥胖大鼠(OLETF)和对照长伊万斯德岛大冢(LETO)大鼠，观察运动训练对I/R损伤的影响。从第19周开始，在机动跑步机上进行为期4周的跑步训练。在离体肝灌流大鼠和麻醉大鼠模型中，OLETF大鼠的I/R肝损伤均大于LETO大鼠。运动训练可预防脂肪肝的发展，减轻I/R损伤，正如在非运动OLETF大鼠中观察到的那样。结论：运动训练可减轻OLETF大鼠脂肪变性肝脏的I/R损伤。

Steatotic livers are known to be vulnerable to ischemia-reperfusion (I/R) injury during hepatic surgery and liver transplantation. Exercise training is recommended to prevent obesity-associated disorders. However, it remains unknown whether exercise training attenuates I/R injury of steatotic liver. We determined, using the hyperphagic, Otsuka Long-Evans Tokushima Fatty (OLETF) rat and the control Long-Evans Tokushima Otsuka (LETO) rat, effects of exercise training on I/R injury under both anesthesia and isolated liver perfusion. Running training was given on a motorized treadmill for four weeks from 19-th week. In both preparations of isolated perfused livers and anesthetized rats, I/R-induced liver injury was greater in the OLETF rats than that of LETO rats. Exercise training prevented the development of steatotic livers and attenuated the I/R injury, as observed in non-exercise OLETF rats. In conclusion, exercise training attenuates I/R injury of steatotic livers from OLETF rats.