Molecular mechanism of short pulse laser retinal photocoagulation in ischemic retina

据报道，短脉冲激光对视网膜内损伤小，疼痛减轻。然而，一些研究人员报道，短脉冲激光对视网膜光凝的效果可能不如传统激光光凝。本研究的目的是确定短脉冲激光光凝对缺血小鼠视网膜的疗效。短脉冲激光对小鼠内视网膜的损伤较小，外侧瘢痕形成的大小为常规激光的70%。与常规激光相比，短脉冲激光对VEGF的抑制作用较小。我们的研究结果表明，当我们使用短脉冲激光时，我们必须进行激光光凝，间距更小，治疗点更多。

Short pulse duration laser has been reported that induced less damage into inner retina and less pain for patients. However, some researchers reported that retinal photocoagulation with short pulse laser might be less effective than that with conventional laser photocoagulation. The purpose of this study was to determine the efficacy of short pulse laser photocoagulation in ischemic murine retina. Short pulse laser induced less damage to the murine inner retina, and the size of lateral scar formation was 70% of that with conventional laser. And the reduction of VEGF was less with short pulse laser compared with conventional laser. Our findings indicated that we have to perform laser photocoagulation with tighter spacing and more number of treatment spots when we use short pulse laser.