The development of the cementum / periodontal membrane reproduction type implant with induced pluripotent stem cells derived from oral mucosa

在口腔上皮源iPS细胞Emdogain和Matarigel与HAT-7细胞共培养的条件下，通过Msx1、Pax9和Matarigel的揭示和共培养，大鼠成牙上皮细胞（HAT-7）表面存在Pax诱导因子和Pax9在大鼠成牙上皮细胞（HAT-7）表面的诱导活性均得到了认可。和Lhx6这两种转录因子是在牙齿生成过程中发现的。虽然使用抗体阵列和Bio-Plex悬浮阵列系统对Emdogain、Matigel和GFR Matarigel中所含的细胞生长因子进行了综合分析，但没有鉴定出细胞生长因子。

Under existence of a lining-of-the-mouth origin iPS cell, Emdogain, and Matarigel, in co-culture with HAT-7 cell, The cell growth of an iPS cell stock, altered morphology, And existence of the Pax inducing factor in the rat odontogenic epithelial cell (HAT-7) surface and the inducible activity of Pax9 in the rat odontogenic epithelial cell (HAT-7) surface were accepted by the revelation and co-culture of Msx1, Pax9, and Lhx6 which are the transcription factors revealed in a dental generating process.Although the cell growth factor contained in Emdogain, Matigel, and GFR Matarigel, was comprehensively analyzed using the antibody array and the Bio-Plex suspension array system, it did not result in identification of a cell growth factor.