Detection of carcinoma cells in peripheral circulation by oncolgtic virus therapy

在本研究中，我们在循环肿瘤细胞模型中研究了携带GFP基因和hTERT基因的腺病毒感染口腔癌细胞后外周循环肿瘤细胞的检测。虽然我们可以证实口腔癌细胞中存在荧光，但荧光与mRNA表达或蛋白质表达之间没有关系。这些结果表明，口腔癌细胞在一定时间内会在外周血流中循环。

In this study, we investigated the detection of peripheral circulating tumor cells by an adenovirus included the GFP gene and the hTERT gene infected to oral carcinoma cells in circulating tumor cell model. Although we could confirm fluorescence in oral carcinoma cells, there were no relation between fluorescence and mRNA expression or protein expression. These results indicated that oral carcinoma cells would be circulate in peripheral blood flow in a certain period.