Spontaneously developed osteoarthritis in the temporomandibular joint in STR/ort mice

对11只30、40、50、60、70周龄的STR/ORT小鼠和6只30、40、60周龄的CBA小鼠的TMJ进行了检测。甲苯胺蓝和抗酒石酸酸性磷酸酶染色评价关节软骨的组织学变化。用显微计算机断层扫描评价关节软骨的形态变化。在40~50周龄时，66%的STR/ORT小鼠关节软骨组织学丢失，裸露的骨空洞和侵蚀，并逐渐改变髁突的形状。此外，通过显微计算机断层扫描观察了骨关节炎的形态变化和结构变化。随着年龄的增长，STR/ORT小鼠品系在TMJ出现自发性骨关节炎样病变，有望成为研究TMJ骨关节炎发病机制的有用模型。

TMJs from 11 STR/ort mice euthanized at 30, 40, 50, 60, or 70 weeks of age, and from six CBA mice euthanized at 30, 40, or 60 weeks of age were examined. Toluidine blue and tartrate-resistant acid phosphatase staining were used to assess histological changes in the articular cartilage. Morphological changes in the articular cartilage of the TMJ were evaluated using micro-computed tomography. At the age of 40 to 50 weeks, 66% of STR/ort mice losed of articular cartilage on histology, with cavitation and erosion of the exposed bone and gradual changes in condylar shape. Furthermore, osteoarthritic morphological changes, and structural alterations were observed by micro-computed tomography. The STR/ort mouse strain appears to be developed spontaneous osteoarthritis-like lesions in the TMJ with age, and would be a useful model to study the pathogenesis of TMJ osteoarthritis.