Taste sensation and QOL in oropharyngeal cancer patients treated by chemo-radiotherapy: A prospective, multicenter clinical study

化疗-放疗（CRT）在口咽癌患者的治疗中非常有效，但伴随着高不良事件发生率。在这项研究中，我们长期跟踪CRT相关的不良事件和生活质量状态的变化。结果显示，不良事件发生在辐射剂量为20戈伊或更高时，即使在CRT完成后9个月也没有消失。患者的体重也明显下降，患者的生活质量在研究期间内没有恢复。这些发现证实，即使在CRT完成后，也需要对患者进行积极干预。

Chemo-radiotherapy (CRT)is highly efficacious in the treatment of oropharyngeal cancer patients, but is accompanied by a high incidence of adverse events. In this study, we followed adverse events and changes in the QOL status associated with CRT over a long term. The results revealed that adverse events occurred at a radiation dose of 20 Gy or higher and they did not disappear even 9 months after the CRT completion. The body weight of the patients also decreased substantially.Patients' QOL was found not to recover after CRT within the studied period. These findings confirm that active interventions on the patients are required even after the CRT completion.