A suppression and separation method of the water solvent signal for the improvement of the accuracy and stability in noninvasive blood glucose measurement

在基于近红外光的无创血糖测量中，为了提高测量的准确性和稳定性，需要抑制水溶剂的信号，这是产生背景噪声的主要原因。在本研究中，我们提出了测量葡萄糖信号的方法，用波长与水分子的最大吸收相对应的激发光照射样品。实验结果表明，从水分子中分离出的信号是有效的。此外，还清楚地表明，基于该方法的测量精度可达到葡萄糖浓度的10%左右。

In a noninvasive blood glucose measurement based on a near infrared light, it is necessary to suppress the signal of the water solvent, which is the main causes of background noise, to improve the accuracy and stability of measurement. In this research, we proposed the method of measuring a glucose signal, irradiating a sample with the excitation light that has a wavelength corresponding to the maximum absorption of the water molecule. It was shown that the signal originated from the water molecule could be separated effectively, as a result of the fundamental experiment. Furthermore, it was shown clearly that glucose concentration could be estimated by about 10% of precision for measurement based on this method.