Integrative Analysis of Structure and Extracellular Environment in Disuse Atrophic Skeletal Muscle

目前我国正面临着一个严重的问题，即超老龄化社会。所有的老年人都能在没有任何身体和社会不适的情况下度过一生，这是非常理想的。 然而，许多老年人由于废用综合征，由于衰老，瘫痪伴脑血管疾病，慢性阻塞性肺病，肌肉减少伴骨折，充血性心力衰竭等，日常生活活动能力差。肌肉萎缩不仅发生在老年人中，而且在暴露于微重力环境的情况下，年轻健康的宇航员也会出现这种情况。骨折导致石膏固定因此，揭示肌肉萎缩的机制和萎缩肌肉的力学特性具有重要意义。 在本研究中，我们利用原子力显微镜进行肌肉细胞被动横向刚度的实验，并利用同步辐射装置进行肌肉组织的x射线衍射实验。

Currently our country is facing a serious problem that the super-aging society. It is quite ideal that all elder people spend their life without being suffering from any physical and social discomfort. However, number of elder people have poor activity of daily life due to disuse syndrome, due to aging, paralysis with cerebral vascular diseases, chronic obstructive pulmonary disease, sarcopenia with fracture, congestive heart failure, and so on. Muscle atrophy is a condition that occurs not only in elder people, but also young healthy people in case of astronauts who is exposed to the microgravity environment, and cast immobilization due to fracture. Thus, it is important to reveal the mechanism of muscle atrophy and mechanical properties of atrophied muscle. In this study, we performed experiments of passive transvers stiffness of muscle cells with an atomic force microscope and x-ray diffraction of muscle tissue in synchrotron radiation facility.