Method to evaluate accurate response waveforms of cardiovascular system to external perturbations and its application to healthcare supports system

评估心血管系统对外部刺激的反应对于理解体内平衡是很重要的。然而，当外部刺激作用的频率与内部波动的频率相匹配时，传统的时域分析会扭曲响应。本研究的目的是提出一种时间域和呼吸相域的混合信号处理方法，提取心跳和血压（BP）对外界刺激的响应波形，阐明心血管系统的反应机制。首先，研究了心血管对吞咽的反应。可准确提取和评估突发性心动过速和血压变化。其次，研究了对姿势变化的反应。证实了收缩压和舒张压的反应波形存在离散性。第三，测试了检测吃惊的应用，并利用心血管反应提高了检测的准确性。总之，所提出的方法在时域内准确地评估心血管系统对外部刺激的响应波形，并考虑生理因素。该方法可用于预防体位性晕厥和触电检测等多种日常生活情况。

It is important to evaluate the response of the cardiovascular system to external stimuli for understanding homeostasis. However, the response should be distorted by the conventional time domain analysis when a frequency of the effect of external stimuli matches that of intrinsic fluctuations. The purpose of this study is to propose a mixed signal processing of time domain and respiratory phase domain to extract the response waveforms of heartbeat and blood pressure (BP) to external stimuli and to clarify the reaction mechanisms of the cardiovascular system.First, cardiovascular responses to swallowing are investigated. Sudden tachycardia and changes of blood pressure is accurately extracted and evaluated. Second, responses to postural changes investigated. It is confirmed that there is dispersion between systolic and diastolic blood pressure as their response waveforms. Third, application to detect startling is tested and the accuracy of the detection is improved using cardiovascular response.In conclusion, the proposed method accurately evaluates response waveforms to external stimuli from the cardiovascular system in the time domain and enable for physiologicalconsiderations. The method would be applicable to several daily-life situations such as prevention of orthostatic syncope and startling detections.