The relationship between Peyer's Paches and intestinal polyps

本实验的目的是阐明在肠道免疫中起核心作用的派伊尔集合淋巴结（Peyer’s Patches，PP）的功能与肠息肉形成之间的相互作用，我们发现在被称为人类结直肠癌模型的ApcMin/+小鼠中，PP的数量与肠息肉的数量之间存在统计学上显著的负相关。然后，我们尝试通过喂饲玉米皮阿拉伯木聚糖（CHAX）来人工增加PP的数量，并检查息肉的形成，当喂饲CHAX增加肠道中PP的数量时，肠息肉的数量在统计学上减少。而Aly-/-ApcMin/+小鼠在肠道无PP时，在CHAX组和对照组之间无显著性差异。由于PP在肠道免疫系统中起着重要作用，因此我们研究了血清中细胞因子的变化。我们发现，当ApcMin/+小鼠喂食CHAX时，IL-1 β，IL-5，IL-10和IL-17降低。

The aim of this experiment is to clarify the interaction between the function of Peyer's Patches(PP), which play a central role in intestinal immunity, and intestinal polyp formation.We found a statistically significant inverse correlation between the number of PP and that of intestinal polyps in ApcMin/+ mice which are known as the model of human colorectal cancer. We, then, tried to increase the number of PP artificially by feeding the Corn Husk Arabinoxylan (CHAX), and examined polyp formation.The number of intestinal polyps was decreased statistically when the number of PP in intestine was increased by feeding the CHAX. On the contrary, there was no significant difference in Aly-/-ApcMin/+ mice which have no PP in intestine when the mice fed with or without CHAX.Since PP has been playing the central role of a gut immunity system, we investigated the change of cytokine in serum. We revealed that IL-1beta, IL-5, IL-10 and IL-17 were decreased when the ApcMin/+ mice fed the CHAX.