Development of chiral nano-space using highly-ordered molecular gel for molecular recognition

含三乙氧基硅基的谷氨酰胺衍生物(CmGDD)是一种新合成的化合物，它能在多种有机溶剂中形成纤维状自组装。CmGDD通过硅氧烷键(sIL-CmGDD)接枝到多孔二氧化硅颗粒表面，用于反相高效液相色谱固定相。固体~(13)C核磁共振和DSC测量表明，CmGDD可以在二氧化硅表面形成高度取向的结构。通过对多环芳烃的保留研究，考察了SIL-C10GDD填充柱的性能。层析结果表明，与传统的十八烷基硅胶相比，Sil-CmGDD对二苯乙烯和三苯基等异构体具有良好的选择性。据估计，这些较好的结果可以通过氢键介导的弱相互作用中心的分子取向，如羰基。SIL-CmGDD还显示了对生育酚、异构体和维生素D等生物相关分子的良好分离。

Glutamide-derivatives with a triethoxysilyl group (CmGDD) was newly synthesized and confirmed to form fibrous self-assembly in various organic solvents. CmGDD was grafted onto the surface of porous silica particles through siloxane bonds (Sil-CmGDD) for use in reversed-phase HPLC as a stationary phase. Solid-state 13C NMR and DSC measurements indicate that CmGDD can form highly-oriented structures on the silica surface. The Sil-C10GDD packed-column was investigated by retention studies of polycyclic aromatic hydrocarbons. The chromatographic results showed that the Sil-CmGDD provided excellent selectivity for these isomers such as stilbenes and terphenyls than conventional octadecylated silica. It is estimated that these preferable results can be brought about through hydrogen bond-mediated molecular orientation of weak interaction sites such as carbonyl groups. Sil-CmGDD also showed excellent separations of bio-related molecules such as tocopherols isomers and Vitamine Ds.