Study of postoperative portal venous thrombosis after splenectomy in cirrhotic patients and its therapeutic implication

目的：探讨脾切除术后门静脉血栓形成（PVT）的发生机制。术前研究显示，PVT组凝血酶原时间较非PVT组延长（p=0.0593），抗凝血酶III值较PVT组降低（p=0.0054）。非PVT组术后几天内抗凝血酶Ⅲ恢复正常，而PVT组术后恢复较晚，术后第7天抗凝血酶Ⅲ明显低于非PVT组（p<0.05）。认为高凝状态可能是脾切除术后肝功能恢复延迟导致PVT的原因之一。

The aim of study is to elucidate the mechanism of portal venous thrombosis (PVT) after splenectomy in cirrhotic patients. Preoperative study showed that prothrombin time was more prolonged in PVT group than in non PVT group (p=0.0593), and value of antithrombin III was lower in PVT group (p=0.0054). In non PVT group, value of antithrombin III was recovered in a few days after splenectomy, however recovery of antithrombin III was delayed in PVT group after splenectomy and value of antithombin III was significantly lower in PVT group on 7thpostoperative day (p<0.05) than in non PVT group. It is supposed that hypercoagulopathy might be one of causes of PVT after splenectomy due to delayed functional recovery of liver.