Mechanism of cell wall thickening in drug-resistant bacteria

以往文献报道，形态敏感菌与耐药菌无明显差异。然而，它具有细胞壁增厚作为超微结构特征的特点，VISA（万古霉素耐药金黄色葡萄球菌）在1997年被发现以来，就引起了人们对细菌细胞壁的关注。我们报道了从慢性鼻窦炎患者分离的ML耐药葡萄球菌的超微结构特征，其形态学特征为细胞壁增厚。我们在本研究中检查了是否具有耐药菌的一般形态学特征。在ML耐药菌的情况下，具有细胞壁增厚的特点，而且对于多重耐药金黄色葡萄球菌也获得了类似的结果，多次耐药菌细胞壁增厚可能有助于蛋白质合成抑制剂。

Conventionally, had been reported that there is no difference in the morphological sensitive bacteria and drug-resistant bacteria. However, it has a feature that cell wall thickening as ultrastructural features VISA (Vancomycin-Resistant Staphylococcus aureus) in 1997 since, it has attracted attention for the bacterial cell wall. We have reported that examined the ultrastructural characteristics for ML -resistant staphylococci isolated from chronic sinusitis patients have morphological characteristics of cell wall thickening. We were examined whether having the morphological characteristics in drug-resistant bacteria in general in this study. In the case of ML -resistant bacteria , has a characteristic of cell wall thickening , but also for multi-drug resistant S. aureus against S. aureus similar results were obtained , cell wall thickening of multiple-drug-resistant bacteria has been pointed out may contribute the protein synthesis inhibitor .