Neutrophils Express Oncomodulin and Promote Optic Nerve Regeneration

我们在这里表明，中性粒细胞，先天免疫系统的第一反应者，在炎症诱导的再生中发挥着核心作用。大量中性粒细胞在诱导炎症反应的几小时内进入小鼠眼睛，并表达高水平的非典型生长因子肿瘤调节蛋白（Ocm）。中性粒细胞的免疫耗竭降低了眼内的OCM水平，而没有改变CNTF、白血病抑制因子或IL-6的水平，并抑制了炎症的促再生作用。OCM的肽拮抗剂抑制再生，有效地作为中性粒细胞耗竭。巨噬细胞在炎症过程中较晚进入眼睛，但在中性粒细胞缺乏的情况下似乎不足以刺激广泛的过度生成。这些数据提供了第一个证据表明，中性粒细胞是OCM的主要来源，可以促进CNS中的轴突再生。

We show here that neutrophils, the first responders of the innate immune system, play a central role in inflammation-induced regeneration. Numerous neutrophils enter the mouse eye within a few hours of inducing an inflammatory reaction and express high levels of the atypical growth factor oncomodulin (Ocm). Immunodepletion of neutrophils diminished Ocm levels in the eye without altering levels of CNTF, leukemia inhibitory factor, or IL-6, and suppressed the proregenerative effects of inflammation. A peptide antagonist of Ocm suppressed regeneration as effectively as neutrophil depletion. Macrophages enter the eye later in the inflammatory process but appear to be insufficient to stimulate extensiveregeneration in the absence of neutrophils. These data provide the first evidence that neutrophils are a major source of Ocm and can promote axon regeneration in the CNS.