Development of a new antioxidant therapy for sepsis using DHLH-Zn, a novel alpha-lipoic acid

我们研究了一种新的α-硫辛酸衍生物组氨酸锌二硫代辛酰胺钠(DHLH-锌)是否对脓毒症有治疗作用。本研究结果表明，双氢黄体生成素锌可通过抑制氧化应激而减轻脓毒症大鼠器官损伤。此外，我们还试图阐明其抗氧化作用的机制。我们尝试用电子自旋共振(ESR)仪建立一些生物样品中氧化不育的评估方法。由于样品中存在多种干扰因素，直接测定氧化菌有一定的难度，但经过认真考虑，提高了测定的准确度。

We investigated whether Sodium Zinc Histidine Dithiooctanamide (DHLH-Zn), a novel alpha-lipoic acid derivative, had therapeutic effect against sepsis. The results of the present study indicated that DHLH-Zn ameliorated sepsis-induced organ damage by suppression of oxidative stress in rat model. In addition, we tried to clarify the mechanism of antioxidative effect. We attempted to establish the assessment method of oxidative steress in some biotic samples with the use of electron spin resonance (ESR) apparatus. It was hard to measure the oxidative steress directly because of various interfering factors in samples, however, we improved the accuracy of measurement after careful consideration.