The combined effect of emdogainRgel and bioactive glass in the healing of cranial bone defect in rats.

本研究的目的是探讨EmdogainRgel（EMD）对根尖周病变内的开放性根尖损伤的影响。给药后28天处死大鼠，准备进行免疫组化检查。治疗后28天，EMD组新生牙骨质的平均面积明显大于对照组。实验结果表明，EMD对根尖周组织破坏后的创面愈合具有良好的促进作用。此外，本研究旨在探讨EMD与生物活性玻璃（BAG）联合应用对大鼠颅骨缺损的修复作用。治疗后第28天，EMD+BAG组的平均新骨形成面积显著大于对照组。这些结果表明，EMD和BAG的组合增强了大鼠颅骨愈合过程，这表明它可能对骨再生有用。

The purpose of this study was to investigate the effects of EmdogainRgel (EMD) on the injured open-apex within the periapical lesions. The rats were sacrificed 28 days after treatment and prepared for immunohistochemical examination. At 28days after the treatment, the mean area of newly formed cementum in the EMD group was significantly larger than in the control group. These results suggest that, EMD may have the benefit efficacy to create a favorable environment promoting wound healing of destroyed periapical tissues.In addition, the purpose of this study was to investigate the combination effects of EMD and bioactive glass(BAG) in the healing of cranial bone defect in rats. At 28 days after the treatment, the mean area of newly formed bone in the EMD+BAG group was significantly larger than that in the control group. These results suggest that a combination of EMD and BAG enhances the cranial bone healing process in rats, suggesting it could be useful for bone regeneration.