Investigation on neural mechanisms of the effect of touch using an indicator of cardiovascular responses to painful stimuli
Investigation on neural mechanisms of the effect of touch using an indicator of cardiovascular responses to painful stimuli
批准号:
23792575
负责人:
WATANABE Nobuhiro
金额:
$2.0万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2011
资助国家:
日本
项目状态:
已结题
起止时间:
2011 至 2012
中文摘要
本研究以心率对伤害性热刺激的反应为指标,研究了温和皮肤刺激(触摸)对麻醉大鼠的影响及其机制。我们发现,使用软弹性刷子的触摸抑制了热诱导的心率反应。此外,通过阻断脊髓μ-阿片受体,触摸对心率反应的抑制作用被取消。
英文摘要
The present study examined the effect of gentle cutaneous stimulation (touch) and its mechanism using heart rate responses to noxious heat stimulation as an indicator in anesthetized rats. We found that touch using a soft elastomer brush inhibited heat-induced heart rate responses. Additionally, the inhibitory effect of touch on heart rate responses was abolished by blocking spinal μ-opioid receptors.
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