Development of slab optical waveguide fluorescent microscopy system for the study of heterogeneous chemical reactions of biochemical agents at lipid membrane

应用由科研代表研制的平板光波导荧光显微镜系统，观察抗菌剂S(GS)对脂膜的破坏作用。该测量系统在玻璃表面稳定的平面类脂膜的观察中具有重要的优势，因为它利用逝去波照明具有很高的界面选择性。研究代表性的是开发了一种环保荧光染料的平面类脂膜的可视化方法。观察GS及其类似物对脂质膜的破坏作用。结果表明，其抗菌活性与抗菌活性具有良好的相关性。

Slab optical waveguide fluorescent microscopy (SOWG-FM) system,which was developed by research representatives was applied to the observation of lipid membrane disruption by antibacterial agent, Gramicidin S (GS). The measurement system has an important advantage in the observation of planar lipid membrane stabilized on a glass surface because its high interfacial selectivity using an evanescent wave illumination.The research representative was developed a visualization method of the planar lipid membrane by an environmentally-responsive fluorescent dye. Lipid membrane disruption by GS and its analog were observed. The results showed good correlation with those antibacterial activities.